Season 2 opens with Cathy seeking a second opinion about her cancer, which doesn't sit well with Dr. Todd. Meanwhile, Sean discovers that his sister is battling cancer while he's dealing with the growing pains of living with a pregnant Rebecca; and Adam is less-than-happy about seeing a therapist.
Problems in the bedroom plague Cathy and Paul, but some insight from their new housemate, Andrea, goes a long way in getting things situated. Meanwhile, newly medicated Sean ruffles Rebecca's feathers; and Adam isn't getting what he wants from his relationship with Mia, so he hooks up with another girl.
Cathy tries dabbling in the supernatural after she's unsuccessful at scoring a spot in a clinical trial for a new cancer treatment overseen by a renowned oncologist (Alan Alda). Meanwhile, Sean takes on a take-charge attitude around the house, and Adam uses his mother's medical situation to his advantage at school. Cathy sees her new oncologist and finds out that a promising clinical trial is already filled up. Rebecca asks Cathy to throw her a babyshower and Sean decides to get better while Adam despises his classmates sympathy.
Cathy threatens her friendship with Dr. Todd when she consults another specialist. Meanwhile her brother Sean tries to come to term with his new life as a soon-to-be father.
